Evidence for a Role of the Lateral Ectoderm in Drosophila Mesoderm Invagination.

ABSTRACT: The folding of two-dimensional epithelial sheets into specific three-dimensional structures is a fundamental tissue construction mechanism in animal development. A common mechanism that mediates epithelial folding is apical constriction, the active shrinking of cell apices driven by actomyosin contractions. It remains unclear whether cells outside of the constriction domain also contribute to folding. During Drosophila mesoderm invagination, ventrally localized mesoderm epithelium undergoes apical constriction and subsequently folds into a furrow. While the critical role of apical constriction in ventral furrow formation has been well demonstrated, it remains unclear whether, and if so, how the laterally localized ectodermal tissue adjacent to the mesoderm contributes to furrow inva

SUBMITTER: Guo H 

PROVIDER: S-EPMC9081377 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature