Mechanistic insight into the photodynamic effect mediated by porphyrin-fullerene C₆₀ dyads in solution and in Staphylococcus aureus cells.

ABSTRACT: The photodynamic action mechanism sensitized by a non-charged porphyrin-fullerene C₆₀ dyad (TCP-C₆₀) and its tetracationic analogue (TCP-C₆₀ ⁴⁺) was investigated in solution and in Staphylococcus aureus cells. The ability of both dyads to form a photoinduced charge-separated state was evidenced by the reduction of methyl viologen in N,N-dimethylformamide (DMF). Moreover, the formation of superoxide anion radicals induced by these dyads was detected by the reduction of nitro blue tetrazolium. Also, photosensitized decomposition of l-tryptophan (Trp) was investigated in the presence of reactive oxygen species (ROS) scavengers. The addition of β-carotene and sodium azide had a slight effect on reaction rate. However, photooxidat

SUBMITTER: Ballatore MB 

PROVIDER: S-EPMC9081455 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature