Pseudocowpox virus, a novel vector to enhance the therapeutic efficacy of antitumor vaccination.

ABSTRACT:

Objective

Antitumor viral vaccines, and more particularly poxviral vaccines, represent an active field for clinical development and translational research. To improve the efficacy and treatment outcome, new viral vectors are sought, with emphasis on their abilities to stimulate innate immunity, to display tumor antigens and to induce a specific T-cell response.

Methods

We screened for a new poxviral backbone with improved innate and adaptive immune stimulation using IFN-α secretion levels in infected PBMC cultures as selection criteria. Assessment of virus effectiveness was made in vitro and in vivo.

Results

The bovine pseudocowpox virus (PCPV) stood out among several poxviruses for its ability to induce significant secretion of IFN-α. PCPV produced effi

SUBMITTER: Ramos RN 

PROVIDER: S-EPMC9081486 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature