Hydrogel microfibers with perfusable folded channels for tissue constructs with folded morphology.

ABSTRACT: Fiber-based materials with microchannels have drawn considerable attention in recent years owing to their ability to mimic intrinsic morphologies of living tissues. Folded morphologies, which are common in vivo, such as in skeletal muscle capillaries and intestine luminal endoderm, play important roles in the achievement of tissue functions. Here, microfibers with folded hollow channels are fabricated. Channel morphologies, such as straight-folded, double-folded and double-helical channels, can be regulated by adjusting flow conditions in the microfluidic devices. To further demonstrate the potential to be used in tissue engineering, intestine and skeletal muscle constructs are fabricated using these microfibers as building blocks. Furthermore, the properties of perfusability, perme

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9081586 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature