Ontology highlight
ABSTRACT:
SUBMITTER: Rinaldi F
PROVIDER: S-EPMC9081591 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Rinaldi Francesca F Tengattini Sara S Piubelli Luciano L Bernardini Roberta R Mangione Francesca F Bavaro Teodora T Paone Gregorino G Mattei Maurizio M Pollegioni Loredano L Filice Gaetano G Temporini Caterina C Terreni Marco M
RSC advances 20180626 41
Tuberculosis is the deadliest infectious disease in the world. The variable efficacy of the current treatments highlights the need for more effective agents against this disease. In the past few years, we focused on the investigation of antigenic glycoconjugates starting from recombinant Ag85B (rAg85B), a potent protein antigen from <i>Mycobacterium tuberculosis</i>. In this paper, structural modifications were rationally designed in order to obtain a rAg85B variant protein able to maintain its ...[more]