Susceptibility of Genetic Variations in Methylation Pathway to Gastric Cancer.

ABSTRACT:

Background

DNA methylation in the CpG island is associated with gastric cancer, genetic variations residue in genes involved in methylation pathway could contribute to the occurrence of gastric cancer. Here, we investigated the association between DNMTs (DNMT1/DNMT3A/DNMT3B), MTHFR genetic variations and gastric cancer risk and patients' survival.

Patients and methods

We recruited 490 gastric cancer patients and 488 age- and sex-matched healthy controls. The genotypes of the genetic variations were detected by a Mass-array platform. A commercial Helicobacter pylori (H. pylori) immunogold testing kit was used to determine the H. pylori infection.

Results

We found that carriers of DNMT1 rs2228612C allele was associated wi

SUBMITTER: Xiong M 

PROVIDER: S-EPMC9081620 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature