Multiple Organ Dysfunction Interactions in Critically Ill Children.

ABSTRACT:

Introduction

Multiple organ dysfunction (MOD) is a common pathway to morbidity and death in critically ill children. Defining organ dysfunction is challenging, as we lack a complete understanding of the complex pathobiology. Current pediatric organ dysfunction criteria assign the same diagnostic value-the same "weight"- to each organ system. While each organ dysfunction in isolation contributes to the outcome, there are likely complex interactions between multiple failing organs that are not simply additive.

Objective

Determine whether certain combinations of organ system dysfunctions have a significant interaction associated with higher risk of morbidity or mortality in critically ill children.

Methods

We conducted a retrospective observational cohort study of critic

SUBMITTER: Badke CM 

PROVIDER: S-EPMC9081807 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature