Serum Lipocalin-2 Levels Are Increased and Independently Associated With Early-Stage Renal Damage and Carotid Atherosclerotic Plaque in Patients With T2DM.

ABSTRACT:

Objectives

Diabetic nephropathy (DN), one of the major complications of diabetes mellitus, is the major cause of end-stage renal failure that finally increases the risk of cardiovascular disease and mortality. The aim of this study is to explore the relationship between serum lipocalin-2 (LCN-2) levels and DN and carotid atherosclerotic plaque (CAP) in patients with type 2 diabetes mellitus (T2DM).

Methods

We have performed a prospective study of 749 T2DM patients with or without DN. Blood samples were collected and used to test serum LCN-2 levels, renal function, as well as biochemical parameters. CAP in these subjects was determined by ultrasonography.

Results

In these 749 subjects with T2DM, an increased morbidity of CAP was observed in T2DM patients with DN as com

SUBMITTER: Gan J 

PROVIDER: S-EPMC9081837 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature