Prognostic value of serum/plasma neurofilament light chain for COVID-19-associated mortality.

ABSTRACT:

Objective

Given the continued spread of coronavirus 2, the early predictors of coronavirus disease 19 (COVID-19) associated mortality might improve patients' outcomes. Increased levels of circulating neurofilament light chain (NfL), a biomarker of neuronal injury, have been observed in severe COVID-19 patients. We investigated whether NfL provides non-redundant clinical value to previously identified predictors of COVID-19 mortality.

Methods

We measured serum or plasma NfL concentrations in a blinded fashion in 3 cohorts totaling 338 COVID-19 patients.

Results

In cohort 1, we found significantly elevated NfL levels only in critically ill COVID-19 patients. Longitudinal cohort 2 data showed that NfL is elevated late in the course of the disease, following the two other

SUBMITTER: Masvekar RR 

PROVIDER: S-EPMC9082006 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature