The Effects of Helicobacter pylori Infection on Gastric Microbiota in Children With Duodenal Ulcer.

ABSTRACT:

Background

Helicobacter pylori (H. pylori) infection is the main cause of chronic gastritis and duodenal ulcer in children. Little is known about the effect of H. pylori on gastric microbiota in children with duodenal ulcer. This study is aimed at the characteristics of gastric microbiota in children with duodenal ulcer on H. pylori infection.

Methods

We studied 23 children diagnosed with duodenal ulcer by gastric endoscopy because of the gastrointestinal symptoms, 15 children were diagnosed with H. pylori infection, while 8 children were without H. pylori infection. Endoscopic mucosal biopsy samples were obtained for DNA extraction. Microbiomes were analyzed by 16S rRNA profiling and microbial functions were predicted using the soft

SUBMITTER: Zheng W 

PROVIDER: S-EPMC9082302 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature