Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders.

ABSTRACT: The glymphatic system, a recently discovered macroscopic waste removal system in the brain, has many unknown aspects, especially its driving forces and relationship with sleep, and thus further explorations of the relationship between the glymphatic system and a variety of possible related diseases are urgently needed. Here, we focus on the progress in current research on the role of the glymphatic system in several common central nervous system diseases and mood disorders, discuss the structural and functional abnormalities of the glymphatic system which may occur before or during the pathophysiological progress and the possible underlying mechanisms. We emphasize the relationship between sleep and the glymphatic system under pathological conditions and summarize the common imaging techni

SUBMITTER: Zhang D 

PROVIDER: S-EPMC9082304 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature