LINC00667 regulates MPP⁺ -induced neuronal injury in Parkinson's disease.

ABSTRACT:

Objective

Parkinson's disease (PD), also known as paralysis tremor, is a chronic disease of the central nervous system. It has been reported that hepatocyte nuclear factor 4 alpha (HNF4A) is upregulated in PD, but its specific function has not been well explored.

Methods

We established an in vitro PD model in SH-SY5Y cells stimulated with 1-methyl-4-phenylpyridinium (MPP⁺ ). Meanwhile, the effect of HNF4A on MPP⁺ -treated SH-SY5Y cell behavior was monitored by functional assays. Mechanism assays were conducted to verify the relationship among LINC00667/miR-34c-5p/HNF4A. Rescue experiments validated the regulatory mechanism in PD model.

Results

The results revealed that depletion of HNF4A suppressed cell cytotoxicity and apoptosis caused by MPP

SUBMITTER: Huo X 

PROVIDER: S-EPMC9082386 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature