Exploring the interaction between Salvia miltiorrhiza and α-glucosidase: insights from computational analysis and experimental studies.

ABSTRACT: α-Glucosidase has emerged as an important target for type 2 diabetes mellitus. Salvia miltiorrhiza is a widely used traditional Chinese medicine. The interaction between the chemicals of S. miltiorrhiza and α-glucosidase are still not clear, and need to be deeply investigated. Herein, an integrated approach consisting of computational analysis and experimental studies was employed to illustrate the interactions between S. miltiorrhiza and α-glucosidase. Molecular docking simulations were performed to reveal the proposed binding characteristics of the chemicals identified in S. miltiorrhiza on the basis of the total docking scores and key molecular determinants for binding. The affinities of 13 representative compounds from the medicinal herb to α-glucosidase wer

SUBMITTER: Tang H 

PROVIDER: S-EPMC9082424 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature