Immune Activities in Choroids of Visually Impaired Smyth Chickens With Autoimmune Vitiligo.

ABSTRACT: Vitiligo is a common dermatological disorder affecting 1-2% of the world's population. It is characterized by postnatal, autoimmune destructions of melanocytes in the skin, resulting in patches of depigmentation. Autoimmunity in vitiligo may also affect melanocytes in non-integumental tissues, including the eyes where choroidal melanocytes are the target of the autoimmune response. The Smyth line (SL) of chicken is the only animal model that spontaneously and predictably develops all clinical and biological manifestations of autoimmune vitiligo. In SL vitiligo (SLV), destruction of epidermal melanocytes in growing feathers (GFs) involves a melanocyte-specific, Th1-mediated cellular immune response. Smyth chickens may also exhibit uveitis and vision impairment. Previous studies established

SUBMITTER: Sorrick J 

PROVIDER: S-EPMC9082495 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature