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Xyloplains A-F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana.

ABSTRACT: Six new guaiane dimers, xyloplains A-F (1-6), with connecting patterns through two direct C-C bonds (C-1 to C-3', C-2 to C-1'), were isolated from the roots of Xylopia vielana. Their structures were elucidated clearly using extensive analysis of 1D NMR and 2D NMR, combined with Cu-Kα X-ray diffraction and circular dichroism (CD) experiments. In additon, all of the isolates were tested for anti-inflammatory activity by measuring the amount of nitric oxide produced. To our delight, compounds 2 and 6 exhibited moderate inhibitory activity against the production of nitric oxide with IC₅₀ value of 34.5 and 31.1 μM, respectively, in RAW264.7 cells stimulated by LPS.

SUBMITTER: Xie YG

PROVIDER: S-EPMC9082531 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Xyloplains A-F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana.

Xie Yang-Guo YG Zhang Weiyue W Zhu Sheng-Lan SL Cheng Tao-Fang TF Wu Guo-Jing GJ Muhammad Ishaq I Yan Shi-Kai SK Zhang Yan Y Jin Hui-Zi HZ Zhang Wei-Dong WD

RSC advances 20180718 45

Six new guaiane dimers, xyloplains A-F (1-6), with connecting patterns through two direct C-C bonds (C-1 to C-3', C-2 to C-1'), were isolated from the roots of Xylopia vielana. Their structures were elucidated clearly using extensive analysis of 1D NMR and 2D NMR, combined with Cu-Kα X-ray diffraction and circular dichroism (CD) experiments. In additon, all of the isolates were tested for anti-inflammatory activity by measuring the amount of nitric oxide produced. To our delight, compound ...[more]

PMID: 35539790

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