Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis.

ABSTRACT:

Objectives

Dysregulated chondrocyte metabolism is closely associated with the pathogenesis of osteoarthritis (OA). Suppressing chondrocyte catabolism to restore cartilage homeostasis has been extensively explored, whereas far less effort has been invested toward enhancing chondrocyte anabolism. This study aimed to repurpose clinically approved drugs as potential stimulators of chondrocyte anabolism in treating OA.

Methods

Screening of a Food and Drug Administration-approved drug library; Assays for examining the chondroprotective effects of digoxin in vitro; Assays for defining the therapeutic effects of digoxin using a surgically-induced OA model; A propensity-score matched cohort study using The Health Improvement Network to examine the relationship between digoxin use and

SUBMITTER: Wang KD 

PROVIDER: S-EPMC9082564 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature