Reduced Preoperative Glomerular Filtration Rate Is Associated With Adverse Postoperative Oncological Prognosis in Patients Undergoing Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Retrospective Cohort Study.

ABSTRACT:

Objective

To evaluate the association between perioperative estimated glomerular filtration rate (eGFR) and postoperative oncological outcomes in patients with upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU),and to evaluate the effect of sex on this association.

Methods

The medical records of patients with UTUC who underwent RNU between January 2012 and December 2017 at our hospital were retrospectively reviewed. Patients were divided into three groups based on preoperative eGFRs: normal eGFR (>60 mL/min/1.73 m²; n = 179), moderately reduced eGFR (45-60 mL/min/1.73 m²; n = 45), and severely reduced eGFR (≤ 45 mL/min/1.73 m²; n = 36). Statistical analyses were performed to evaluate the

SUBMITTER: Li S 

PROVIDER: S-EPMC9082599 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature