Anticoagulant drugs with or without proton pump inhibitor and colorectal cancer risk: a population-based, case-control study.

ABSTRACT:

Background

Low-dose aspirin and clopidogrel have demonstrated potential chemoprevention for colorectal cancer (CRC). Proton-pump inhibitors (PPI) are commonly prescribed with anticoagulation drugs, but the relationship between PPI and CRC is unclear. Moreover, evidence of CRC risk under direct oral anticoagulant (DOAC) is limited. This study aimed to investigate the effects of anticoagulation drugs combined with or without PPI on the risks of CRC in Taiwan.

Methods

A retrospective case-control study of 1,024,227 cases based on the Chang Gung Research Database from 2010 to 2017 was performed. Clinical characteristics, indications, duration of anticoagulation and PPI use, and CRC occurrence data were collected. Logistic regression was employed to adjust for known confounders o

SUBMITTER: Ho PH 

PROVIDER: S-EPMC9082832 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature