A retrospective longitudinal cohort study of the clinical burden in myasthenia gravis.

ABSTRACT:

Background

Patients with generalized myasthenia gravis (MG) often experience debilitating exacerbations, with the possibility of life-threatening respiratory crises requiring hospitalization. Long-term longitudinal studies are needed to understand the burden of MG, including in patients whose disease is refractory to conventional treatment.

Methods

A retrospective, longitudinal, cohort study was conducted of patients in England aged ≥ 18 years with treatment-refractory or non-refractory MG, using data recorded during 1997-2016 in the Clinical Practice Research Datalink and the Hospital Episode Statistics databases. A control cohort of patients without MG, matched to the patients in the treatment-refractory MG cohort, was also identified. Outcome measures included myasthenic

SUBMITTER: Harris L 

PROVIDER: S-EPMC9082838 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature