Comprehensive and integrative analyses identify TYW5 as a schizophrenia risk gene.

ABSTRACT:

Background

Identifying the causal genes at the risk loci and elucidating their roles in schizophrenia (SCZ) pathogenesis remain significant challenges. To explore risk variants associated with gene expression in the human brain and to identify genes whose expression change may contribute to the susceptibility of SCZ, here we report a comprehensive integrative study on SCZ.

Methods

We systematically integrated the genetic associations from a large-scale SCZ GWAS (N = 56,418) and brain expression quantitative trait loci (eQTL) data (N = 175) using a Bayesian statistical framework (Sherlock) and Summary data-based Mendelian Randomization (SMR). We also measured brain structure of 86 first-episode antipsychotic-naive schizophrenia patients and 152 healthy controls with the struc

SUBMITTER: Zhang C 

PROVIDER: S-EPMC9082878 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature