Associations of NAFLD with circulating ceramides and impaired glycemia.

ABSTRACT:

Aim

Determine the association of circulating ceramides with NAFLD and glycemic impairment.

Methods

Sample: 669 participants in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) cohort aged 40-84 years without cardiovascular disease, cirrhosis, or significant alcohol intake.

Clinical measures

Computed tomography scans at baseline for hepatic attenuation. Fasting serum specimens at baseline and after 5 years. Lipidomics: LC-MS-based analysis of 19 known ceramide signals.

Statistical analysis

Linear and logistic regression models of log-transformed ceramides, hepatic attenuation and glucose adjusted for age, sex, calories, study site, BMI, exercise, diet quality, alcohol, saturated fat, lipid-lowering medications and fasting glucose.

R

SUBMITTER: Gadgil MD 

PROVIDER: S-EPMC9082931 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature