Is Hearing Impairment Causally Associated With Falls? Evidence From a Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

Observational studies have suggested that hearing impairment (HI) was associated with the risk of falls, but it remains unclear if this association is of causal nature.

Methods

A two-sample Mendelian randomization (MR) study was conducted to investigate the causal association between HI and falls in individuals of European descent. Summary data on the association of single nucleotide polymorphisms (SNPs) with HI were obtained from the hitherto largest genome-wide association study (GWAS) (n = 323,978), and statistics on the association of SNPs with falls were extracted from another recently published GWAS (n = 461,725). MR Steiger filtering method was applied to determine the causal direction between HI and falls. Inverse-variance weighted (IVW) meth

SUBMITTER: Wang J 

PROVIDER: S-EPMC9082948 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature