Genome-wide identification of associations between enhancer and alternative splicing in human and mouse.

ABSTRACT:

Background

Alternative splicing (AS) increases the diversity of transcriptome and could fine-tune the function of genes, so that understanding the regulation of AS is vital. AS could be regulated by many different cis-regulatory elements, such as enhancer. Enhancer has been experimentally proved to regulate AS in some genes. However, there is a lack of genome-wide studies on the association between enhancer and AS (enhancer-AS association). To bridge the gap, here we developed an integrative analysis on a genome-wide scale to identify enhancer-AS associations in human and mouse.

Result

We collected enhancer datasets which include 28 human and 24 mouse tissues and cell lines, and RNA-seq datasets which are paired with the selected tissues. Combining with data integration and

SUBMITTER: Shiau CK 

PROVIDER: S-EPMC9082955 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature