Robust microfluidic construction of hybrid microfibers based on konjac glucomannan and their drug release performance.

ABSTRACT: The exploration of methods to produce a novel wound dressing with sustained drug release properties in ultrasmall scales is of great scientific and technological interest. Herein, we propose konjac glucomannan/polyvinylidene fluoride (KGM/PVDF) hybrid microfibers having hydrophilic and hydrophobic segments based on microfluidic-oriented core-sheath composite microfibers, where the KGM/PVDF hybrid microfibers are wrapped in situ in CH₃OH. The morphology of KGM/PVDF microfibers is uniform, smooth, and crack-free. Enrofloxacin (Enro) is loaded onto the microfibers as a representative cargo to test their release performance. The KGM/PVDF/Enro microfibers show sustained drug release performance (13 days), excellent heat resistance, antibacterial activity and promotion of wound

SUBMITTER: Ni Y 

PROVIDER: S-EPMC9083025 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature