Immunotherapeutic Significance of a Prognostic Alternative Splicing Signature in Bladder Cancer.

ABSTRACT: Objectives: Bladder cancer is the fourth most common malignancy in men in the United States. Aberrant alternative splicing (AS) events are involved in the carcinogenesis, but the association between AS and bladder cancer remains unclear. This study aimed to construct an AS-based prognostic signature and elucidate the role of the tumor immune microenvironment (TIME) and the response to immunotherapy and chemotherapy in bladder cancer. Methods: Univariate Cox regression analysis was performed to detect prognosis-related AS events. The least absolute shrinkage and selection operator (LASSO) and multivariate Cox analyses were employed to build prognostic signatures. Kaplan-Meier survival analysis, multivariate Cox regression analysis, and receiver operating characteristic (ROC) c

SUBMITTER: Chen J 

PROVIDER: S-EPMC9083046 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature