Respiratory plasticity following spinal cord injury: perspectives from mouse to man.

ABSTRACT: The study of respiratory plasticity in animal models spans decades. At the bench, researchers use an array of techniques aimed at harnessing the power of plasticity within the central nervous system to restore respiration following spinal cord injury. This field of research is highly clinically relevant. People living with cervical spinal cord injury at or above the level of the phrenic motoneuron pool at spinal levels C3-C5 typically have significant impairments in breathing which may require assisted ventilation. Those who are ventilator dependent are at an increased risk of ventilator-associated co-morbidities and have a drastically reduced life expectancy. Pre-clinical research examining respiratory plasticity in animal models has laid the groundwork for clinical trials. Despite how wi

SUBMITTER: Locke KC 

PROVIDER: S-EPMC9083159 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature