Calcitriol Inhibits Proliferation and Potentially Induces Apoptosis in B16-F10 Cells.

ABSTRACT: BACKGROUND Melanoma is one of the most aggressive types of cancer and it has shown a remarkable surge in incidence during the last 50 years. Melanoma has been projected to be continuously rising in the future. Therapy for advanced-type melanoma is still a challenge due to the low response rate and poor 10-year survival. Interestingly, several epidemiological and preclinical studies had reported that vitamin D deficiency was associated with disease progression in several cancer types. In vivo and in vitro studies revealed anti-proliferative, anti-angiogenic, apoptosis, and differentiation induction effects of calcitriol in various cancers. However, information on the effects of calcitriol (1,25(OH)₂D₃) on melanoma is still limited, and its mechanism remains unclear. MATERIAL AND METHODS In

SUBMITTER: Sutedja EK 

PROVIDER: S-EPMC9083216 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature