Practice Effects in Mild Cognitive Impairment Increase Reversion Rates and Delay Detection of New Impairments.

ABSTRACT:

Objective

Cognitive practice effects (PEs) can delay detection of progression from cognitively unimpaired to mild cognitive impairment (MCI). They also reduce diagnostic accuracy as suggested by biomarker positivity data. Even among those who decline, PEs can mask steeper declines by inflating cognitive scores. Within MCI samples, PEs may increase reversion rates and thus impede detection of further impairment. Within an MCI sample at baseline, we evaluated how PEs impact prevalence, reversion rates, and dementia progression after 1 year.

Methods

We examined 329 baseline Alzheimer's Disease Neuroimaging Initiative MCI participants (mean age = 73.1; SD = 7.4). We identified test-naïve participants who were demographically matched to returnees at their 1-year follow-up.

SUBMITTER: Sanderson-Cimino M 

PROVIDER: S-EPMC9083463 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature