Particulate matter (PM₁₀) induces in vitro activation of human neutrophils, and lung histopathological alterations in a mouse model.

ABSTRACT: The epidemiological association between exposure to particulate matter (PM₁₀) and various respiratory and cardiovascular problems is well known, but the mechanisms driving these effects remain unclear. Neutrophils play an essential role in immune defense against foreign agents and also participate in the development of inflammatory responses. However, the role of these cells in the PM₁₀ induced inflammatory response is not yet fully established. Thus, this study aims to evaluate the effect of PM₁₀ on the neutrophil-mediated inflammatory response. For this, neutrophils from healthy adult human donors were in vitro exposed to different concentrations of PM₁₀. The cell viability and cytotoxic activity were evaluated by MTT. LDH, propidium iodide and

SUBMITTER: Valderrama A 

PROVIDER: S-EPMC9083477 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature