Synthesis of β-alkoxy-N-protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening.

ABSTRACT: A regioselective, copper-catalyzed, one-pot aminoalkoxylation of styrenes using primary and secondary alcohols and three different iminoiodanes as alkoxy and nitrogen sources respectively, is reported. The β-alkoxy-N-protected phenethylamines obtained were used to synthesise β-alkoxy-N-benzylphenethylamines which are interesting new compounds that could act as possible neuronal ligands.

SUBMITTER: Saavedra-Olavarria J 

PROVIDER: S-EPMC9083506 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature