Visfatin inhibits colon cancer cell apoptosis and decreases chemosensitivity to 5‑FU by promoting the SDF‑1/CXCR4/Akt axis.

ABSTRACT: 5‑Fluorouracil (5‑FU) is the preferred chemotherapeutic drug used in the treatment of colon cancer; however, drug resistance affects its clinical efficacy. Visfatin, an adipokine that promotes tumour development, has the potential to increase resistance to chemotherapy. The present study aimed to verify the effects of visfatin on the sensitivity of colon cancer cells to 5‑FU and to elucidate the potential mechanisms involved. Tissue microarrays (TMAs) were used to analyse visfatin differential expression in normal colon and colon cancer tissues, and the data were further validated in vitro. Cell Counting Kit‑8, clone formation, caspase‑3/7 activity assays, as well as other analyses were used to verify the effects of visfatin on sensitivity to 5‑FU. TMA and correlation analyses were

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC9083850 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature