Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Background

The ability to increase heart rate during exercise and other stressors is a key homeostatic feature of the sinoatrial node (SAN). When the physiological heart rate response is blunted, chronotropic incompetence limits exercise capacity, a common problem in patients with heart failure with preserved ejection fraction (HFpEF). Despite its clinical relevance, the mechanisms of chronotropic incompetence remain unknown.

Methods

Dahl salt-sensitive rats fed a high-salt diet and C57Bl6 mice fed a high-fat diet and an inhibitor of constitutive nitric oxide synthase (Nω-nitro-L-arginine methyl ester [L-NAME]; 2-hit) were used as models of HFpEF. Myocardial infarction was created to induce HF with reduced ejection fraction. Rats and mice fed with a normal diet or those that

SUBMITTER: Mesquita T 

PROVIDER: S-EPMC9083886 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature