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N²-selective alkylation of NH-1,2,3-triazoles with vinyl ethers via gold catalysis.

ABSTRACT: A new method was developed to synthesize N²-alkyl-substituted 1,2,3-triazoles via gold catalyzed alkylation of vinyl ethers with mono- and unsubstituted NH-1,2,3-triazoles and benzotriazole. A hydrogen bond between the oxygen atom of the vinyl ethers, activated via the gold catalyst, and the NH-1,2,3-triazoles was supposed to be generated, which selectively gave the N²-alkylation products.

SUBMITTER: Luo G

PROVIDER: S-EPMC9083898 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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N2-selective alkylation of NH-1,2,3-triazoles with vinyl ethers via gold catalysis.

Luo Guoli G Sun Chenyang C Li Yan Y Li Xiaoxiao X Zhao Zhigang Z

RSC advances 20180802 49

A new method was developed to synthesize N2-alkyl-substituted 1,2,3-triazoles via gold catalyzed alkylation of vinyl ethers with mono- and unsubstituted NH-1,2,3-triazoles and benzotriazole. A hydrogen bond between the oxygen atom of the vinyl ethers, activated via the gold catalyst, and the NH-1,2,3-triazoles was supposed to be generated, which selectively gave the N2-alkylation products. ...[more]

PMID: 35542727

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