Histamine Potentiates SARS-CoV-2 Spike Protein Entry Into Endothelial Cells.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes coronavirus disease (COVID-19) is one of the most serious global health crises in recent history. COVID-19 patient symptoms range from life-threatening to mild and asymptomatic, which presents unique problems in identifying, quarantining, and treating the affected individuals. The emergence of unusual symptoms among survivors, now referred to as "Long COVID", is concerning, especially since much about the condition and the treatment of it is still relatively unknown. Evidence so far also suggests that some of these symptoms can be attributed to vascular inflammation. Although famotidine, the commonly used histamine H2 receptor (H2R) blocker, was shown to have no antiviral activity, recent reports indicate that it cou

SUBMITTER: Raghavan S 

PROVIDER: S-EPMC9084361 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature