Anticancer activities of a β-amino alcohol ligand and nanoparticles of its copper(ii) and zinc(ii) complexes evaluated by experimental and theoretical methods.

ABSTRACT: 2-(2-(2-Hydroxyethylamino)ethylamino)cyclohexanol (HEAC) and copper and zinc complexes, [Cu(HEAC)Cl]Cl (1), [Cu(HEAC)Br]Br (2), [Zn(HEAC)Cl₂] (3), were prepared and identified by elemental analysis, FT-IR, UV-Vis, ¹H NMR spectroscopy and single-crystal X-ray diffraction. Also nanoparticles of 1-3 were prepared for anticancer studies by ultrasonic irradiation. Particle size and morphology of the nano particles are investigated by PXRD and SEM, respectively. X-ray analysis revealed that the ionic complexes 1 and 2 are isostructural. In the structure of complexes 1 and 2, the metal atom has a CuN₂O₂X (X: Cl (1), Br (2)) environment with square-pyramidal geometry, containing the tetradentate N₂O₂-donor HEAC. The bond length of t

SUBMITTER: Mardani Z 

PROVIDER: S-EPMC9084389 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature