Effect of Antimicrobial Prophylaxis on Corynebacterium bovis Infection and the Skin Microbiome of Immunodeficient Mice.

ABSTRACT: Corynebacterium bovis is an opportunistic pathogen of the skin of immunodeficient mice and is sensitive to oral antibiotics that reach therapeutic blood concentrations. However, prophylactic antibiotics are considered to be ineffective at preventing C. bovis infection. In addition, the effect of C. bovis on the skin microbiome (SM) of common immunodeficient mouse strains has yet to be characterized. Consequently, we evaluated whether oral prophylactic antibiotics prevent C. bovis infection after inoculation. An infectious dose of C. bovis was applied to the skin of Hsd:Athymic Nude (nude) and NOD. Cg-Prkdc^{scid Il2rgtm1Wjl}/SzJ (NSG) mice. Mice were then housed individually and assigned randomly to receive either untreated drinking water (

SUBMITTER: Manuel CA 

PROVIDER: S-EPMC9084569 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature