EphrinB2 expression in prostate adenocarcinoma: Implications for targeted therapy.

ABSTRACT:

Background

Prostate cancer is managed by surgery, androgen deprivation and cytotoxic chemotherapy. Targeted therapy is emerging as an important pillar in cancer therapeutics, however, efficacy in prostate cancer has been limited. Eph-ephrin is a novel pathway that is upregulated in prostate cancer and promotes the initiation and progression of cancer. The aim of this study was to determine the immunohistochemical expression of ephrinB2 in prostate adenocarcinoma.

Methods

A tissue microarray comprising of prostate adenocarcinoma of different grade groups was stained with a monoclonal anti-ephrinB2 antibody (Abcam, AB201512). The tumor and endothelial cells expressing the ephrinB2 positivity were noted. The statistical analysis was performed to determine the difference in expr

SUBMITTER: Gupta C 

PROVIDER: S-EPMC9084634 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature