Density-Dependent Migration Characteristics of Cancer Cells Driven by Pseudopod Interaction.

ABSTRACT: The ability of cancer cells to invade neighboring tissue from primary tumors is an important determinant of metastatic behavior. Quantification of cell migration characteristics such as migration speed and persistence helps to understand the requirements for such invasiveness. One factor that may influence invasion is how local tumor cell density shapes cell migration characteristics, which we here investigate with a combined experimental and computational modeling approach. First, we generated and analyzed time-lapse imaging data on two aggressive Triple-Negative Breast Cancer (TNBC) cell lines, HCC38 and Hs578T, during 2D migration assays at various cell densities. HCC38 cells exhibited a counter-intuitive increase in speed and persistence with increasing density, whereas Hs578T did not

SUBMITTER: Burger GA 

PROVIDER: S-EPMC9084912 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature