MiRNA-142-3p functions as a potential tumor suppressor directly targeting FAM83D in the development of ovarian cancer.

ABSTRACT:

Background

FAM83D (family with sequence similarity 83, member D) is of particular interest in tumorigenesis and tumor progression. Ovarian cancer is the leading cause of cancer-related death in women all over the world. This study aims to research the association between FAM83D and ovarian cancer (OC).

Methods

The gene expression data of OC and normal samples (GSE81873 and GSE27651) was downloaded from Gene Expression Omnibus (GEO) dataset. The bioinformatics analysis was performed to distinguish two differentially expressed genes (DEGs), prognostic candidate genes and functional enrichment pathways. Immunohistochemistry (IHC), Quantitative Real-time PCR (qPCR), and luciferase reporter assays were utilized for further study.

Results

There were 56 DEMs and 63 DEGs in c

SUBMITTER: Gao G 

PROVIDER: S-EPMC9085228 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature