Dataset Information

Molecular networking prospection and characterization of terpenoids and C₁₅-acetogenins in Brazilian seaweed extracts.

ABSTRACT: Molecular networking (MN) can efficiently dereplicate extracts and pure compounds. Red algae of the genus Laurencia are rich in halogenated secondary metabolites, mainly sesquiterpenes and C₁₅-acetogenins. Brown algae of the genus Dictyopteris produce mainly C₁₁-hydrocarbons, sesquiterpenes and sulfur-containing compounds, while Dictyota and Canistrocarpus are reported to contain mainly diterpenes. This study performs an exploratory MN analysis of 14 extracts from algae collected in Brazil (including the oceanic islands) and characterizes the secondary metabolites from the analyzed species. The extracts and some isolated metabolites were analyzed by LC-MS using the FastDDA algorithm, and the MS/MS spectra were submitted to GNPS and displayed in Cytoscape 3.5.1. The GNPS platform generated 68 individual nodes and nine family networks. The MN exploratory analysis indicated chemical differences among species, and also in sampling sites for the same species. For some extracts, it was possible to identify mass values that could correspond to terpenoids and C₁₅-acetogenins that have already been isolated from those or related species. An interesting chemodiversity was highlighted between Laurencia catarinensis from two nearby islands, and this was revealed and was also suggested by the family networks. Many nodes in the MN could not be characterized, and these metabolites can be used as targets for isolation in future works.

SUBMITTER: Philippus AC

PROVIDER: S-EPMC9085288 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Publications

Molecular networking prospection and characterization of terpenoids and C15-acetogenins in Brazilian seaweed extracts.

Philippus Ana Cláudia AC Zatelli Gabriele A GA Wanke Tauana T Gabriela de A Barros Maria M Kami Satomy A SA Lhullier Cintia C Armstrong Lorene L Sandjo Louis P LP Falkenberg Miriam M

RSC advances 20180821 52

Molecular networking (MN) can efficiently dereplicate extracts and pure compounds. Red algae of the genus Laurencia are rich in halogenated secondary metabolites, mainly sesquiterpenes and C15-acetogenins. Brown algae of the genus Dictyopteris produce mainly C11-hydrocarbons, sesquiterpenes and sulfur-containing compounds, while Dictyota and Canistrocarpus are reported to contain mainly diterpenes. This study performs an exploratory MN analysis o ...[more]

PMID: 35547298

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Dataset Information

Molecular networking prospection and characterization of terpenoids and C₁₅-acetogenins in Brazilian seaweed extracts.

Publications

Molecular networking prospection and characterization of terpenoids and C<sub>15</sub>-acetogenins in Brazilian seaweed extracts.

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