Tumor Suppressor Role and Clinical Significance of the FEV Gene in Prostate Cancer.

ABSTRACT:

Background

In our previous research, we developed a 32-gene risk index model that may be utilized as a robust prognostic method for predicting prostate cancer (PCa) recurrence after surgery. Among the 32 genes, the Fifth Ewing Variant (FEV) gene was one of the top downregulated genes in relapsed PCa. However, current understanding of the FEV gene and its involvement in PCa is limited.

Methods

FEV mRNA expression was analyzed and correlated to clinical outcomes in PCa patients who underwent prostatectomy at the Massachusetts General Hospital. Specimens from tissue microarray (TMA) including 102 prostate cancer patients were analysis for the expression of FEV. Meanwhile, FEV expression profiles were also assessed in PCa cell lines and in BPH-1 prostate epithelial cells

SUBMITTER: Liang YX 

PROVIDER: S-EPMC9085333 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature