Silica-coated magnetic iron oxide functionalized with hydrophobic polymeric ionic liquid: a promising nanoscale sorbent for simultaneous extraction of antidiabetic drugs from human plasma prior to their quantitation by HPLC.

ABSTRACT: Herein, silica-coated iron oxide nanoparticles modified with imidazolium-based polymeric ionic liquid (Fe₃O₄@SiO₂@PIL) were fabricated as a sustainable sorbent for magnetic solid-phase extraction (MSPE) and simultaneous determination of trace antidiabetic drugs in human plasma by high-performance liquid chromatography-ultraviolet detection (HPLC-UV). The Fe₃O₄ core was functionalized by silica (SiO₂) and vinyl layers where the ionic liquid 1-vinyl-3-octylimidazolium bromide (VOIM-Br) was attached through a free radical copolymerization process. In order to achieve hydrophobic magnetic nanoparticles and increase the merits of the sorbent, Br^- anions were synthetically replaced with PF₆ ^-. The

SUBMITTER: Badragheh S 

PROVIDER: S-EPMC9085437 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature