Translocator Protein (18 kDa) Polymorphism (rs6971) in the Korean Population.

ABSTRACT:

Background and purpose

The expression of the 18-kDA mitochondrial translocator protein (TSPO) in the brain is an attractive target to study neuroinflammation. However, the binding properties of TSPO ligands are reportedly dependent on genetic polymorphism of the TSPO gene (rs6971). The objective of this study is to investigate the rs6971 gene polymorphism in the Korean population.

Methods

We performed genetic testing on 109 subjects including patients with mild cognitive impairment, Alzheimer's disease (AD) dementia, non-AD dementia, and cognitively unimpaired participants. Magnetic resonance imaging scans and detailed neuropsychological tests were also performed, and 29 participants underwent ¹⁸F-DPA714 PET scans. Exon 4 of the TSPO gene containing the polymorphi

SUBMITTER: Lee H 

PROVIDER: S-EPMC9085532 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature