[Pan-cancer analysis of the expression pattern of long non-coding RNA MIR22HG].

ABSTRACT:

Objective

To conduct a pan-cancer analysis of the expression of long non-coding RNA (lncRNA) MIR22HG and explore its association with clinical characteristics.

Methods

We analyzed the expression of MIR22HG in different tumors and its association with clinical staging, lymph node metastasis, tumor mutation burden (TMB) and microsatellite instability (MSI) using R package based on the Cancer Genome Atlas (TCGA) datasets. The relationship between MIR22HG expression and infiltrating immune cells was analyzed using TIMER algorithm. The association of MIR22HG gene alteration frequency with the clinical outcomes was examined using cBioPortal online software. Data form Genomics of Drug Sensitivity in Cancer (GDSC) were used to analyze the relationship between MIR22HG and the sensiti

SUBMITTER: Wang H 

PROVIDER: S-EPMC9085579 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature