[METTL27 is a prognostic biomarker of colon cancer and associated with immune invasion].

ABSTRACT:

Objective

To investigate the expression and gene function of methyltransferase-like protein 27 (METTL27) in colon cancer, its association with immune infiltration and its prognostic significance.

Methods

We analyzed the expression levels of METTL27 in 33 cancers using R language and identified METTL27 as a differential gene in colon cancer. The related signaling pathways of METTL27 were analyzed by gene functional annotation and enrichment. SsGSEA algorithm was used to analyze immune infiltration, and logistic analysis was used to evaluate the correlation between METTL27 expression and clinicopathological features of the patients. Kaplan-meier analysis, univariate and multivariate Cox regression analysis were performed to construct a nomogram for evaluating the correlation b

SUBMITTER: Wang K 

PROVIDER: S-EPMC9085597 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature