Soluble α-Klotho levels, glycemic control and renal function in US adults with type 2 diabetes.

ABSTRACT:

Aims

Soluble Klotho (s-Klotho) is associated with chronic kidney disease (CKD) and aging, but little is known on its relationship with chronic micro- and macro-vascular complications of type 2 diabetes and glycemic control. Here, we evaluate the association between s-Klotho levels, glycemic control and renal function in patients with type 2 diabetes (T2D).

Methods

This is a cross-sectional study including 2989 patients with T2D and available s-Klotho measurements from the 2007-2016 cycles of the National Health and Nutrition Examination Survey (mean ± SE, age: 60.0 ± 0.2 years, BMI 33.3 ± 0.2 kg/m², 46.7 ± 1.3% female). Determination of s-Klotho concentrations was performed with a sandwich ELISA test.

Results

Patients with higher s-Klotho levels were younge

SUBMITTER: Ciardullo S 

PROVIDER: S-EPMC9085659 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature