Analysis of the genomic landscapes of Barbadian and Nigerian women with triple negative breast cancer.

ABSTRACT:

Purpose

Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionately affects women of African ancestry (WAA) and is often associated with poor survival. Although there is a high prevalence of TNBC across West Africa and in women of the African diaspora, there has been no comprehensive genomics study to investigate the mutational profile of ancestrally related women across the Caribbean and West Africa.

Methods

This multisite cross-sectional study used 31 formalin-fixed paraffin-embedded (FFPE) samples from Barbadian and Nigerian TNBC participants. High-resolution whole exome sequencing (WES) was performed on the Barbadian and Nigerian TNBC samples to identify their mutational profiles and comparisons were made to African American, Europ

SUBMITTER: Hercules SM 

PROVIDER: S-EPMC9085672 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature