PAM50 subtyping and ROR score add long-term prognostic information in premenopausal breast cancer patients.

ABSTRACT: PAM50 intrinsic subtyping and risk of recurrence (ROR) score are approved for risk profiling in postmenopausal women. We aimed to examine their long-term prognostic value in terms of breast cancer-free interval (BCFi) and overall survival (OS) (n = 437) in premenopausal women randomised to 2 years of tamoxifen versus no systemic treatment irrespective of hormone-receptor status. Intrinsic subtyping added independent prognostic information in patients with oestrogen receptor-positive/human epidermal growth factor 2-negative tumours for BCFi and OS after maximum follow-up (overall P-value 0.02 and 0.006, respectively) and those with high versus low ROR had worse prognosis (maximum follow-up: hazard ratio (HR)_BCFi: 1.70, P = 0.04). The prognostic information by ROR was similar rega

SUBMITTER: Lundgren C 

PROVIDER: S-EPMC9085780 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature