Learning induces coordinated neuronal plasticity of metabolic demands and functional brain networks.

ABSTRACT: The neurobiological basis of learning is reflected in adaptations of brain structure, network organization and energy metabolism. However, it is still unknown how different neuroplastic mechanisms act together and if cognitive advancements relate to general or task-specific changes. Therefore, we tested how hierarchical network interactions contribute to improvements in the performance of a visuo-spatial processing task by employing simultaneous PET/MR neuroimaging before and after a 4-week learning period. We combined functional PET and metabolic connectivity mapping (MCM) to infer directional interactions across brain regions. Learning altered the top-down regulation of the salience network onto the occipital cortex, with increases in MCM at resting-state and decreases during task execut

SUBMITTER: Klug S 

PROVIDER: S-EPMC9085889 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature