A preliminary study on the association between epithelial-mesenchymal transition and circulating tumor cells in renal cell carcinoma.

ABSTRACT:

Background

Circulating tumor cells (CTCs) are considered useful prognostic factors for various cancers, and in 2014, our research group conducted a comparative experiment of CTC detection in patients with renal cell cancer (RCC). However, the reason for the low detection rate of CTCs in cancer patients using the CellSearch^® system is still unknown, although it has been hypothesized to be attributed to the likelihood that CTCs undergoing epithelial-mesenchymal transition (EMT) do not express the CTC biomarkers cytokeratin (CK)8/18/19 or epithelial cell adhesion molecule (EpCAM). The overall aim of the current study was to investigate the expression levels of CK8/18/19 and EpCAM in relation to the EMT biomarkers vimentin and E-cadherin in patients with RCC.

Methods

SUBMITTER: Wang H 

PROVIDER: S-EPMC9085926 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature